Off-Grid Adventure Delays Nobel Prize News for One Medicine Laureate

The 2025 Nobel Prize in Medicine has been awarded to Fred Ramsdell, Mary Brunkow, and Shimon Sakaguchi for their groundbreaking discoveries related to the immune system. However, the Nobel committee is facing an unusual challenge: they’ve been unable to reach co-recipient Fred Ramsdell, who is currently on an ‘off the grid’ hiking trip, reportedly in the Idaho backcountry.

Ramsdell, a senior adviser at Sonoma Biotherapeutics, shares the prestigious award with Mary Brunkow of Seattle, Washington, and Shimon Sakaguchi of Osaka University, Japan. Their collective work identified the immune system’s crucial ‘security guards,’ known as regulatory T-cells, and elucidated their role in preventing the immune system from attacking the body. This research on ‘peripheral immune tolerance’ has opened new avenues for medical treatments currently undergoing clinical trials.

While the committee eventually made contact with Brunkow despite the time difference, Ramsdell’s digital detox has left them unable to deliver the momentous news personally. Jeffrey Bluestone, a friend and co-founder of Ramsdell’s lab, confirmed the researcher’s passion for the outdoors, stating, ‘I think he may be backpacking in the backcountry in Idaho.’ The committee, led by secretary-general Thomas Perlmann, continues its efforts to inform the elusive laureate of his recognition.

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